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Background:Diabetic retinopathy (DR) is a sight-threatening microvascular complication of diabetes in which the vascular endothelium is damaged due to oxidative stress and inflammation, and vitreous VEGF concentration becomes elevated. The aim of the present study was to assess the association of DR with genetic variations of the MnSOD, a major antioxidant enzyme, and VEGF, an important mediator of neovascularisation, in northern Iran. Methods: 70 patients with DR and 70 healthy control subjects matched for age and sex was recruited for this study. PCR-based RFLP assay was used to determine the genotypes of MnSODA16V and VEGF+405 C/G polymorphisms. Results and Conclusions:A higher frequency of the AV genotype (71.43%) of the MnSODA16V polymorphism was found in the patients compared with controls which had a 8.33-fold increase in risk of DR (OR= 8.33, 95% CI= 2.56-27.13, P= 0.0004). The frequency of GG, GC, and CC genotypes of VEGF +405 C/G polymorphism in controls were 42.86%, 45.71% and 11.43%, respectively, while in DR patients were 18.57%, 48.57%, and 32.86%, respectively.The +405C allele was considered as a high risk factor of DR (OR= 2.55, 95% CI= 1.57-4.14, P= 0.0001). In conclusion, It is suggested that the MnSODA16V and the VEGF+405 C/G polymorphisms may be associated with the risk of DR in northern Iran.

Keywords: Diabetic retinopathy, gene polymorphism, VEGF andMnSOD

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